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Syndrome reference sheet
Generated 12 Oct 2026
Infectious Disease · Infectious disease / Bacterial infections

Jarisch–Herxheimer reaction syndrome

Also known as: JHR

Fever and rigors after antibiotic treatment of spirochetal infection.

Medical specialty
Infectious Disease
Subspecialty
Infectious disease / Bacterial infections
Sex & age distribution
Male: affected; Female: affected; Children: yes
Gene(s) involved
None recorded

Etiology & mechanism

Cytokine release from dying spirochetes.

Gene(s) involved (0)

No gene recorded.

Symptoms & signs (5)

feverheadachehypotensionmyalgiarigors
SyndromeScope — educational reference. Content is model-generated and not clinically verified; always confirm against OMIM, Orphanet and GeneReviews before clinical use.