Iridocorneal endothelial syndrome

Also known as: Chandler syndrome; Cogan–Reese syndrome; ICE syndrome

Abnormal corneal endothelium proliferation causing iris changes and glaucoma.

Medical specialty: Ophthalmology
Subspecialty: Ophthalmology / Glaucoma
Sex & age distribution: Male: affected; Female: affected, female predominance; Children: rare, onset 20–50 years
Gene(s) involved: None recorded

Etiology & mechanism

Herpes virus-triggered endothelial cell proliferation proposed.

Gene(s) involved (0)

No gene recorded.

Symptoms & signs (6)

corectopiacorneal edemairis atrophyiris nodulesperipheral anterior synechiaesecondary glaucoma

SyndromeScope — educational reference. Content is model-generated and not clinically verified; always confirm against OMIM, Orphanet and GeneReviews before clinical use.