Insulin autoimmune syndrome

Also known as: Hirata disease

Spontaneous hypoglycemia from insulin autoantibodies.

Medical specialty: Endocrinology
Subspecialty: Endocrinology / Diabetes
Sex & age distribution: Male: affected; Female: affected; Children: rare
Gene(s) involved: HLA-DRB1*04:06

Etiology & mechanism

Antibodies bind and release endogenous insulin.

Gene(s) involved (1)

HLA-DRB1*04:06

Symptoms & signs (5)

confusionhigh total insulinpalpitationspostprandial hypoglycemiasweating

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