Infant respiratory distress syndrome

Also known as: Hyaline membrane disease; Neonatal respiratory distress syndrome

Surfactant deficiency in preterm infants causing respiratory failure.

Medical specialty: Pulmonology
Subspecialty: Pulmonology / Neonatal lung disease
Sex & age distribution: Male: affected, higher risk; Female: affected; Children: yes, preterm neonates
Gene(s) involved: ABCA3, NKX2-1, SFTPB, SFTPC

Etiology & mechanism

Immature type II pneumocytes with insufficient surfactant.

Gene(s) involved (4)

ABCA3NKX2-1SFTPBSFTPC

Symptoms & signs (6)

chest retractionscyanosisground-glass chest filmgruntingnasal flaringtachypnea

SyndromeScope — educational reference. Content is model-generated and not clinically verified; always confirm against OMIM, Orphanet and GeneReviews before clinical use.