Hereditary leiomyomatosis and renal cell cancer syndrome

Also known as: HLRCC; Reed syndrome

Cutaneous and uterine leiomyomas with aggressive papillary renal cell carcinoma.

Medical specialty: Nephrology
Subspecialty: Nephrology / Renal oncology
Sex & age distribution: Male: affected; Female: affected equally; Children: rare, adults
Gene(s) involved: FH

Etiology & mechanism

Fumarate hydratase loss.

Gene(s) involved (1)

Symptoms & signs (5)

cutaneous leiomyomasflank painhematuriatype 2 papillary renal cell carcinomauterine fibroids

SyndromeScope — educational reference. Content is model-generated and not clinically verified; always confirm against OMIM, Orphanet and GeneReviews before clinical use.