Heparin-induced thrombocytopenia syndrome

Also known as: HIT

Immune-mediated thrombocytopenia with thrombosis after heparin exposure.

Medical specialty: Hematology
Subspecialty: Hematology / Thrombosis and hemostasis
Sex & age distribution: Male: affected; Female: affected; Children: rare
Gene(s) involved: FCGR2A

Etiology & mechanism

Antibodies to platelet factor 4–heparin complexes activate platelets.

Gene(s) involved (1)

FCGR2A

Symptoms & signs (3)

skin necrosisthrombocytopenia 5–10 days after heparinvenous and arterial thrombosis

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