HELLP syndrome

Also known as: Hemolysis, elevated liver enzymes, low platelets

Severe pregnancy complication with hemolysis, elevated liver enzymes and thrombocytopenia.

Medical specialty: Obstetrics and Gynecology
Subspecialty: Obstetrics and Gynecology / Obstetric complications
Sex & age distribution: Male: not affected; Female: affected, pregnant women; Children: no
Gene(s) involved: FLT1, HADHA, HLA-G, LCHAD

Etiology & mechanism

Placental ischemia with endothelial injury and microangiopathy.

Gene(s) involved (4)

FLT1HADHAHLA-GLCHAD

Symptoms & signs (7)

headachehypertensionjaundicenauseaproteinuriaright upper quadrant painthrombocytopenia

SyndromeScope — educational reference. Content is model-generated and not clinically verified; always confirm against OMIM, Orphanet and GeneReviews before clinical use.