Harlequin syndrome

Also known as: Harlequin sign

Unilateral facial flushing and sweating with contralateral anhidrosis.

Medical specialty: Dermatology
Subspecialty: Dermatology / Sweating disorders
Sex & age distribution: Male: affected; Female: affected; Children: yes, neonatal cases
Gene(s) involved: None recorded

Etiology & mechanism

Sympathetic denervation on one side of the face.

Gene(s) involved (0)

No gene recorded.

Symptoms & signs (3)

contralateral anhidrosisfacial asymmetryunilateral flushing

SyndromeScope — educational reference. Content is model-generated and not clinically verified; always confirm against OMIM, Orphanet and GeneReviews before clinical use.