Hand–foot syndrome

Also known as: Dactylitis in sickle cell disease

Painful swelling of hands and feet in infants with sickle cell disease.

Medical specialty: Hematology
Subspecialty: Hematology / Hemoglobinopathies
Sex & age distribution: Male: affected; Female: affected; Children: yes, 6 months to 2 years
Gene(s) involved: HBB

Etiology & mechanism

Vaso-occlusion in small bones.

Gene(s) involved (1)

HBB

Symptoms & signs (3)

feverirritabilitypainful swelling of hands and feet

SyndromeScope — educational reference. Content is model-generated and not clinically verified; always confirm against OMIM, Orphanet and GeneReviews before clinical use.