Gilbert syndrome

Also known as: Gilbert–Meulengracht syndrome

Benign mild unconjugated hyperbilirubinemia.

Medical specialty: Gastroenterology
Subspecialty: Gastroenterology / Hepatology
Sex & age distribution: Male: affected, 2–7:1 male predominance; Female: affected; Children: yes, appears at puberty
Gene(s) involved: SLCO1B1, UGT1A1

Etiology & mechanism

Reduced UGT1A1 expression from TA-repeat promoter polymorphism.

Gene(s) involved (2)

SLCO1B1UGT1A1

Symptoms & signs (5)

abdominal discomfortasymptomaticfatigueicterus with fastingintermittent jaundice

SyndromeScope — educational reference. Content is model-generated and not clinically verified; always confirm against OMIM, Orphanet and GeneReviews before clinical use.