Fibromyalgia syndrome

Also known as: Fibrositis

Chronic widespread pain with fatigue and sleep disturbance.

Medical specialty: Rheumatology
Subspecialty: Rheumatology / Soft tissue disorders
Sex & age distribution: Male: affected; Female: affected, 7:1; Children: yes, adolescents
Gene(s) involved: COMT, SLC6A4

Etiology & mechanism

Central sensitization.

Gene(s) involved (2)

COMTSLC6A4

Symptoms & signs (6)

cognitive difficultiesfatigueheadachesleep disturbancetender pointswidespread pain

SyndromeScope — educational reference. Content is model-generated and not clinically verified; always confirm against OMIM, Orphanet and GeneReviews before clinical use.