Fetal alcohol syndrome

Also known as: FAS

Prenatal alcohol exposure causing facial dysmorphism and neurodevelopmental impairment.

Medical specialty: Psychiatry
Subspecialty: Psychiatry / Substance use disorders
Sex & age distribution: Male: affected; Female: affected, equal; Children: yes, congenital
Gene(s) involved: ADH1B, ALDH2

Etiology & mechanism

Teratogenic effect of ethanol on neural crest and brain.

Gene(s) involved (2)

ADH1BALDH2

Symptoms & signs (6)

growth restrictionintellectual disabilitymicrocephalyshort palpebral fissuressmooth philtrumthin upper lip

SyndromeScope — educational reference. Content is model-generated and not clinically verified; always confirm against OMIM, Orphanet and GeneReviews before clinical use.