Felty syndrome

Also known as: Rheumatoid arthritis with neutropenia and splenomegaly

Triad of rheumatoid arthritis, neutropenia and splenomegaly.

Medical specialty: Hematology
Subspecialty: Hematology / Autoimmune cytopenias
Sex & age distribution: Male: affected; Female: affected, more common; Children: no
Gene(s) involved: HLA-DRB1*04

Etiology & mechanism

Autoimmune neutrophil destruction.

Gene(s) involved (1)

HLA-DRB1*04

Symptoms & signs (5)

leg ulcersneutropeniarecurrent infectionsrheumatoid arthritissplenomegaly

SyndromeScope — educational reference. Content is model-generated and not clinically verified; always confirm against OMIM, Orphanet and GeneReviews before clinical use.