Evans syndrome

Also known as: Autoimmune hemolytic anemia with immune thrombocytopenia

Combined autoimmune hemolytic anemia and immune thrombocytopenia.

Medical specialty: Hematology
Subspecialty: Hematology / Autoimmune cytopenias
Sex & age distribution: Male: affected; Female: affected; Children: yes
Gene(s) involved: CTLA4, FAS, LRBA, PIK3CD, STAT3, TNFRSF6

Etiology & mechanism

Autoantibodies against red cells and platelets; often secondary to immune dysregulation.

Gene(s) involved (6)

CTLA4FASLRBAPIK3CDSTAT3TNFRSF6

Symptoms & signs (7)

bruisingfatiguejaundicelymphadenopathypallorpetechiaesplenomegaly

SyndromeScope — educational reference. Content is model-generated and not clinically verified; always confirm against OMIM, Orphanet and GeneReviews before clinical use.