Empty sella syndrome

Also known as: Primary or secondary empty sella

Herniation of subarachnoid space into the sella with flattened pituitary.

Medical specialty: Endocrinology
Subspecialty: Endocrinology / Pituitary disorders
Sex & age distribution: Male: affected; Female: affected, more common; Children: yes, rare
Gene(s) involved: POU1F1, PROP1

Etiology & mechanism

Defective diaphragma sellae or post-treatment atrophy.

Gene(s) involved (2)

POU1F1PROP1

Symptoms & signs (6)

csf rhinorrheaheadachehyperprolactinemiahypopituitarismmenstrual irregularityvisual disturbance

SyndromeScope — educational reference. Content is model-generated and not clinically verified; always confirm against OMIM, Orphanet and GeneReviews before clinical use.