Dubin–Johnson syndrome

Also known as: Chronic idiopathic jaundice

Benign conjugated hyperbilirubinemia with black liver.

Medical specialty: Gastroenterology
Subspecialty: Gastroenterology / Hepatology
Sex & age distribution: Male: affected; Female: affected, equal; Children: yes, adolescence
Gene(s) involved: ABCC2

Etiology & mechanism

Defective canalicular MRP2 transporter.

Gene(s) involved (1)

ABCC2

Symptoms & signs (5)

abdominal discomfortblack liverdark urinehepatomegalymild jaundice

SyndromeScope — educational reference. Content is model-generated and not clinically verified; always confirm against OMIM, Orphanet and GeneReviews before clinical use.