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Syndrome reference sheet
Generated 12 Oct 2026
Infectious Disease · Infectious disease / Viral infections

Dengue shock syndrome

Also known as: DSS

Severe dengue with plasma leakage and shock.

Medical specialty
Infectious Disease
Subspecialty
Infectious disease / Viral infections
Sex & age distribution
Male: affected; Female: affected; Children: yes
Gene(s) involved
HLA-A*24, MICB, PLCE1

Etiology & mechanism

Antibody-dependent enhancement and cytokine surge.

Gene(s) involved (3)

HLA-A*24MICBPLCE1

Symptoms & signs (5)

bleedingfeverhypotensionplasma leakagethrombocytopenia
SyndromeScope — educational reference. Content is model-generated and not clinically verified; always confirm against OMIM, Orphanet and GeneReviews before clinical use.