Cytokine release syndrome

Also known as: CRS

Systemic inflammation after CAR-T or bispecific antibody therapy.

Medical specialty: Oncology
Subspecialty: Oncology / Oncologic emergencies
Sex & age distribution: Male: affected; Female: affected; Children: yes
Gene(s) involved: IL6

Etiology & mechanism

Massive release of IL-6, IFN-gamma and other cytokines.

Gene(s) involved (1)

IL6

Symptoms & signs (6)

feverhypotensionhypoxiaorgan dysfunctionrashtachycardia

SyndromeScope — educational reference. Content is model-generated and not clinically verified; always confirm against OMIM, Orphanet and GeneReviews before clinical use.