Cronkhite–Canada syndrome

Also known as: Gastrointestinal polyposis with ectodermal changes

Non-hereditary gastrointestinal polyposis with alopecia, nail atrophy and hyperpigmentation.

Medical specialty: Dermatology
Subspecialty: Dermatology / Acquired polyposis syndromes
Sex & age distribution: Male: affected, slight male predominance; Female: affected; Children: rare, onset after age 50
Gene(s) involved: None recorded

Etiology & mechanism

Unknown; possibly autoimmune.

Gene(s) involved (0)

No gene recorded.

Symptoms & signs (7)

alopeciadiarrheahyperpigmentationnail atrophyprotein-losing enteropathytaste lossweight loss

SyndromeScope — educational reference. Content is model-generated and not clinically verified; always confirm against OMIM, Orphanet and GeneReviews before clinical use.