CREST syndrome

Also known as: Limited cutaneous systemic sclerosis

Calcinosis, Raynaud phenomenon, esophageal dysmotility, sclerodactyly and telangiectasia.

Medical specialty: Rheumatology
Subspecialty: Rheumatology / Autoimmune connective tissue disease
Sex & age distribution: Male: affected; Female: affected, more common; Children: rare
Gene(s) involved: HLA-DQA1, HLA-DRB1*01

Etiology & mechanism

Anticentromere antibody associated limited scleroderma.

Gene(s) involved (2)

HLA-DQA1HLA-DRB1*01

Symptoms & signs (6)

calcinosisesophageal dysmotilitypulmonary hypertensionraynaud phenomenonsclerodactylytelangiectasia

SyndromeScope — educational reference. Content is model-generated and not clinically verified; always confirm against OMIM, Orphanet and GeneReviews before clinical use.