Corticobasal syndrome

Also known as: Corticobasal syndrome (CBS)

Clinical syndrome of asymmetric rigidity, apraxia and cortical sensory loss.

Medical specialty: Neurology
Subspecialty: Neurology / Movement disorders; Behavioral neurology
Sex & age distribution: Male: affected; Female: slightly more common; Children: no
Gene(s) involved: GRN, MAPT, TARDBP

Etiology & mechanism

Heterogeneous pathology: corticobasal degeneration, PSP, Alzheimer disease or FTLD-TDP.

Gene(s) involved (3)

GRNMAPTTARDBP

Symptoms & signs (7)

alien limbaphasiaapraxiaasymmetric limb rigiditycortical sensory lossdystoniamyoclonus

Note

Overlaps #70

SyndromeScope — educational reference. Content is model-generated and not clinically verified; always confirm against OMIM, Orphanet and GeneReviews before clinical use.