Cold agglutinin syndrome

Also known as: CAS

Cold-antibody autoimmune hemolytic anemia.

Medical specialty: Hematology
Subspecialty: Hematology / Hemolytic anemias
Sex & age distribution: Male: affected; Female: affected, slightly more; Children: rare
Gene(s) involved: None recorded

Etiology & mechanism

IgM antibodies bind red cells at low temperature.

Gene(s) involved (0)

No gene recorded.

Symptoms & signs (5)

acrocyanosiscold intolerancedark urinefatiguehemolytic anemia

SyndromeScope — educational reference. Content is model-generated and not clinically verified; always confirm against OMIM, Orphanet and GeneReviews before clinical use.