Churg–Strauss syndrome

Also known as: Eosinophilic granulomatosis with polyangiitis

Small-vessel vasculitis with asthma and eosinophilia, often affecting the heart.

Medical specialty: Cardiology
Subspecialty: Cardiology / Rheumatologic cardiology
Sex & age distribution: Male: affected; Female: affected; Children: rare
Gene(s) involved: HLA-DQ, HLA-DRB4

Etiology & mechanism

ANCA and eosinophil-mediated injury.

Gene(s) involved (2)

HLA-DQHLA-DRB4

Symptoms & signs (8)

asthmacardiomyopathyeosinophiliaheart failureneuropathypericarditissinusitisskin purpura

SyndromeScope — educational reference. Content is model-generated and not clinically verified; always confirm against OMIM, Orphanet and GeneReviews before clinical use.