Chronic fatigue syndrome

Also known as: Myalgic encephalomyelitis

Disabling fatigue with post-exertional malaise.

Medical specialty: Psychiatry
Subspecialty: Psychiatry / Stress-related disorders
Sex & age distribution: Male: affected; Female: affected, 2–4:1 female predominance; Children: yes, adolescents
Gene(s) involved: HLA-DQA1, HLA-DRB1

Etiology & mechanism

Immune, autonomic and metabolic dysregulation after infection.

Gene(s) involved (2)

HLA-DQA1HLA-DRB1

Symptoms & signs (6)

cognitive impairmentdisabling fatiguemyalgiaorthostatic intolerancepost-exertional malaiseunrefreshing sleep

SyndromeScope — educational reference. Content is model-generated and not clinically verified; always confirm against OMIM, Orphanet and GeneReviews before clinical use.