Carney complex

Also known as: Carney syndrome

Multiple neoplasia syndrome with cardiac myxomas, skin pigmentation and endocrine tumors.

Medical specialty: Cardiology
Subspecialty: Cardiology / Cardiac oncology
Sex & age distribution: Male: affected; Female: affected equally; Children: yes, myxomas in adolescents
Gene(s) involved: PDE11A, PDE8B, PRKACA, PRKAR1A

Etiology & mechanism

PRKAR1A haploinsufficiency leads to protein kinase A overactivity.

Gene(s) involved (4)

PDE11APDE8BPRKACAPRKAR1A

Symptoms & signs (8)

acromegalyblue nevicardiac myxomaslentiginesprimary pigmented nodular adrenocortical diseaseschwannomasspotty skin pigmentationtesticular tumors

SyndromeScope — educational reference. Content is model-generated and not clinically verified; always confirm against OMIM, Orphanet and GeneReviews before clinical use.