Carcinoid heart disease

Also known as: Hedinger syndrome; Hedinger–Jones syndrome

Right-sided valvular fibrosis from serotonin-secreting neuroendocrine tumors.

Medical specialty: Cardiology
Subspecialty: Cardiology / Oncologic cardiology
Sex & age distribution: Male: affected; Female: affected; Children: rare
Gene(s) involved: MEN1

Etiology & mechanism

Serotonin and vasoactive substances cause plaque-like fibrous deposits on right heart valves.

Gene(s) involved (1)

MEN1

Symptoms & signs (8)

diarrheaedemafatigueflushingpulmonary stenosisright heart failuretricuspid regurgitationwheezing

SyndromeScope — educational reference. Content is model-generated and not clinically verified; always confirm against OMIM, Orphanet and GeneReviews before clinical use.