Caplan syndrome

Also known as: Rheumatoid pneumoconiosis

Rheumatoid arthritis with multiple lung nodules in dust-exposed workers.

Medical specialty: Pulmonology
Subspecialty: Pulmonology / Occupational lung disease
Sex & age distribution: Male: affected, male predominance; Female: affected; Children: no
Gene(s) involved: HLA-DR4

Etiology & mechanism

Exaggerated immune response to mineral dust in rheumatoid disease.

Gene(s) involved (1)

HLA-DR4

Symptoms & signs (5)

arthritiscoughdyspneamultiple pulmonary nodulesrheumatoid factor positivity

SyndromeScope — educational reference. Content is model-generated and not clinically verified; always confirm against OMIM, Orphanet and GeneReviews before clinical use.