Atypical hemolytic uremic syndrome

Also known as: aHUS

Complement-mediated thrombotic microangiopathy not caused by Shiga toxin.

Medical specialty: Nephrology
Subspecialty: Nephrology / Thrombotic microangiopathies
Sex & age distribution: Male: affected; Female: affected; Children: yes
Gene(s) involved: C3, CD46, CFB, CFH, CFI, DGKE, PLG, THBD

Etiology & mechanism

Uncontrolled alternative complement pathway activation.

Gene(s) involved (8)

C3CD46CFBCFHCFIDGKEPLGTHBD

Symptoms & signs (6)

acute kidney injuryanemiafatiguehypertensionneurologic involvementthrombocytopenia

SyndromeScope — educational reference. Content is model-generated and not clinically verified; always confirm against OMIM, Orphanet and GeneReviews before clinical use.