Adie tonic pupil syndrome

Also known as: Holmes–Adie syndrome

Tonic dilated pupil with absent deep tendon reflexes.

Medical specialty: Ophthalmology
Subspecialty: Ophthalmology / Strabismus and neuro-ophthalmology
Sex & age distribution: Male: affected; Female: affected, 2.6:1 female predominance; Children: rare, onset 20–40 years
Gene(s) involved: None recorded

Etiology & mechanism

Postganglionic parasympathetic denervation of the ciliary ganglion.

Gene(s) involved (0)

No gene recorded.

Symptoms & signs (6)

blurred near visiondilated pupilhyporeflexialight-near dissociationphotophobiasegmental iris palsy

SyndromeScope — educational reference. Content is model-generated and not clinically verified; always confirm against OMIM, Orphanet and GeneReviews before clinical use.