Acquired immunodeficiency syndrome

Also known as: AIDS; HIV infection stage 3

Advanced HIV infection with severe CD4 T-cell depletion.

Medical specialty: Infectious Disease
Subspecialty: Infectious disease / Viral infections
Sex & age distribution: Male: affected; Female: affected, rising proportion; Children: yes, vertical transmission
Gene(s) involved: CCR2, CCR5, HLA-B*35, HLA-B*57, TRIM5

Etiology & mechanism

HIV-1 infection destroying CD4 cells.

Gene(s) involved (5)

CCR2CCR5HLA-B*35HLA-B*57TRIM5

Symptoms & signs (7)

diarrheafeverkaposi sarcomalymphadenopathynight sweatsopportunistic infectionsweight loss

SyndromeScope — educational reference. Content is model-generated and not clinically verified; always confirm against OMIM, Orphanet and GeneReviews before clinical use.