/* SyndromeScope — design system */
:root{
  --bg:#0b0f1a; --bg2:#0e1424; --panel:rgba(22,30,50,.72); --panel-solid:#141c31;
  --stroke:rgba(255,255,255,.08); --stroke2:rgba(255,255,255,.14);
  --ink:#eaf0ff; --ink-soft:#9fb0d0; --ink-dim:#6c7ba0;
  --brand:#7c5cff; --brand2:#22d3ee; --accent:#f472b6;
  --gene:#34d399; --symptom:#fbbf24; --syndrome:#7c5cff; --spec:#22d3ee; --related:#f472b6;
  --ok:#34d399; --warn:#fbbf24; --bad:#f87171;
  --radius:18px; --radius-sm:12px; --shadow:0 20px 60px -20px rgba(0,0,0,.6);
  --maxw:1180px;
}
:root[data-theme="light"]{
  --bg:#f4f6fc; --bg2:#eef1fb; --panel:rgba(255,255,255,.82); --panel-solid:#ffffff;
  --stroke:rgba(16,24,48,.08); --stroke2:rgba(16,24,48,.16);
  --ink:#121a30; --ink-soft:#44527a; --ink-dim:#7a86a8;
  --shadow:0 20px 50px -24px rgba(40,50,90,.4);
}
*{box-sizing:border-box}
html,body{margin:0;padding:0}
body{
  font:400 16px/1.6 'Inter',system-ui,sans-serif; color:var(--ink);
  background:var(--bg); min-height:100vh; -webkit-font-smoothing:antialiased;
  overflow-x:hidden;
}
h1,h2,h3{line-height:1.15;margin:0 0 .4em}
h1{font-family:'Fraunces',serif;font-weight:600;letter-spacing:-.5px}
a{color:inherit;text-decoration:none}
button{font-family:inherit}

/* ambient orbs */
.bg-orbs{position:fixed;inset:0;z-index:-1;overflow:hidden;filter:blur(70px);opacity:.5}
.bg-orbs span{position:absolute;width:42vw;height:42vw;border-radius:50%;}
.bg-orbs span:nth-child(1){background:radial-gradient(circle,var(--brand),transparent 60%);top:-10vw;left:-8vw}
.bg-orbs span:nth-child(2){background:radial-gradient(circle,var(--brand2),transparent 60%);top:20vh;right:-14vw}
.bg-orbs span:nth-child(3){background:radial-gradient(circle,var(--accent),transparent 60%);bottom:-18vw;left:30vw}

/* header */
header.site{
  position:sticky;top:0;z-index:50;display:flex;align-items:center;justify-content:space-between;
  gap:16px;padding:14px clamp(16px,4vw,40px);
  background:linear-gradient(to bottom,var(--bg),transparent);backdrop-filter:blur(6px);
}
.brand{display:flex;align-items:center;gap:10px;font-weight:800;font-size:1.15rem}
.brand-mark{font-size:1.4rem;filter:drop-shadow(0 4px 10px rgba(124,92,255,.5))}
.brand-name{background:linear-gradient(90deg,var(--brand),var(--brand2));-webkit-background-clip:text;background-clip:text;color:transparent}
.site-nav{display:flex;align-items:center;gap:6px}
.site-nav a{padding:8px 14px;border-radius:999px;color:var(--ink-soft);font-weight:500;font-size:.95rem;transition:.2s}
.site-nav a:hover{color:var(--ink);background:var(--panel)}
.site-nav a.on{color:var(--ink);background:var(--panel);border:1px solid var(--stroke)}
.theme-toggle{margin-left:6px;width:38px;height:38px;border-radius:50%;border:1px solid var(--stroke);
  background:var(--panel);color:var(--ink);cursor:pointer;font-size:1.1rem;transition:.2s}
.theme-toggle:hover{transform:rotate(25deg)}

.wrap{max-width:var(--maxw);margin:0 auto;padding:clamp(16px,3vw,32px)}

/* hero + search */
.hero{text-align:center;padding:clamp(24px,6vw,64px) 0 24px}
.hero h1{font-size:clamp(2.1rem,6vw,3.6rem);margin-bottom:.2em}
.hero .sub{color:var(--ink-soft);font-size:clamp(1rem,2.4vw,1.2rem);max-width:640px;margin:0 auto 10px}
.counts{display:flex;gap:8px;justify-content:center;flex-wrap:wrap;margin-top:18px}
.counts .chip{background:var(--panel);border:1px solid var(--stroke);border-radius:999px;padding:7px 14px;font-size:.85rem;color:var(--ink-soft)}
.counts .chip b{color:var(--ink)}

.searchbox{position:relative;max-width:720px;margin:26px auto 0}
.mode-tabs{display:flex;gap:6px;justify-content:center;margin-bottom:12px;flex-wrap:wrap}
.mode-tabs button{
  border:1px solid var(--stroke);background:var(--panel);color:var(--ink-soft);
  padding:8px 16px;border-radius:999px;cursor:pointer;font-weight:500;font-size:.9rem;transition:.2s
}
.mode-tabs button.on{color:#fff;background:linear-gradient(90deg,var(--brand),var(--accent));border-color:transparent}
.search-field{display:flex;align-items:center;gap:10px;background:var(--panel-solid);
  border:1px solid var(--stroke2);border-radius:16px;padding:6px 6px 6px 18px;box-shadow:var(--shadow)}
.search-field:focus-within{border-color:var(--brand)}
.search-field input{flex:1;border:0;background:none;outline:none;color:var(--ink);font-size:1.05rem;padding:12px 0}
.search-field .go{border:0;background:linear-gradient(90deg,var(--brand),var(--brand2));color:#fff;
  padding:12px 18px;border-radius:12px;cursor:pointer;font-weight:600}
.chips-in{display:flex;flex-wrap:wrap;gap:6px;align-items:center;flex:1}
.chips-in .tag{display:inline-flex;align-items:center;gap:6px;background:rgba(124,92,255,.18);
  border:1px solid var(--stroke2);border-radius:999px;padding:4px 6px 4px 12px;font-size:.85rem}
.chips-in .tag button{border:0;background:none;color:var(--ink-soft);cursor:pointer;font-size:1rem;line-height:1}
.chips-in input{border:0;background:none;outline:none;color:var(--ink);min-width:140px;flex:1;padding:8px 0}

/* autocomplete dropdown */
.ac{position:absolute;left:0;right:0;top:calc(100% + 8px);z-index:40;background:var(--panel-solid);
  border:1px solid var(--stroke2);border-radius:14px;box-shadow:var(--shadow);overflow:hidden;display:none}
.ac.show{display:block}
.ac .row{display:flex;align-items:center;gap:10px;padding:10px 14px;cursor:pointer;border-bottom:1px solid var(--stroke)}
.ac .row:last-child{border-bottom:0}
.ac .row:hover,.ac .row.sel{background:rgba(124,92,255,.14)}
.ac .dot{width:9px;height:9px;border-radius:50%;flex:none}
.ac .lbl{font-weight:500}
.ac .kind{font-size:.72rem;text-transform:uppercase;letter-spacing:.5px;color:var(--ink-dim);border:1px solid var(--stroke);border-radius:6px;padding:1px 6px}
.ac .meta{margin-left:auto;color:var(--ink-dim);font-size:.82rem}
.dot.gene{background:var(--gene)} .dot.symptom{background:var(--symptom)}
.dot.syndrome{background:var(--syndrome)} .dot.related{background:var(--related)}

/* cards & layout */
.grid{display:grid;gap:18px}
.cols-2{grid-template-columns:repeat(auto-fit,minmax(300px,1fr))}
.card{background:var(--panel);border:1px solid var(--stroke);border-radius:var(--radius);
  padding:20px 22px;backdrop-filter:blur(12px)}
.card h2,.card h3{display:flex;align-items:center;gap:8px}
.card .eyebrow{font-size:.74rem;text-transform:uppercase;letter-spacing:1.2px;color:var(--ink-dim);font-weight:600}
.muted{color:var(--ink-soft)}
.dim{color:var(--ink-dim)}

.section-title{display:flex;align-items:center;gap:10px;margin:28px 0 14px}
.section-title h2{margin:0;font-size:1.3rem}
.section-title .count{color:var(--ink-dim);font-size:.9rem}

/* result list */
.res-list{display:grid;gap:10px}
.res{display:block;background:var(--panel);border:1px solid var(--stroke);border-radius:var(--radius-sm);
  padding:14px 16px;transition:.18s}
.res:hover{border-color:var(--brand);transform:translateY(-2px)}
.res .name{font-weight:600;font-size:1.05rem}
.res .sub{color:var(--ink-soft);font-size:.9rem;margin-top:2px}
.res .bar{height:6px;border-radius:4px;background:var(--stroke);margin-top:10px;overflow:hidden}
.res .bar span{display:block;height:100%;background:linear-gradient(90deg,var(--brand),var(--brand2))}
.res .scorebadge{float:right;font-size:.8rem;color:var(--ink-dim)}

/* pills */
.pill{display:inline-flex;align-items:center;gap:6px;padding:6px 12px;border-radius:999px;
  border:1px solid var(--stroke2);background:var(--panel);font-size:.88rem;margin:3px 4px 3px 0;transition:.15s;cursor:pointer}
.pill:hover{border-color:var(--brand);color:var(--ink)}
.pill.gene{border-color:rgba(52,211,153,.4)} .pill.symptom{border-color:rgba(251,191,36,.35)}
.pill .d{width:8px;height:8px;border-radius:50%}
.pills{margin:4px 0 2px}

/* syndrome detail */
.detail-head{display:flex;flex-wrap:wrap;gap:16px;align-items:flex-start;justify-content:space-between;margin-bottom:8px}
.detail-head .spec-tag{background:linear-gradient(90deg,var(--brand),var(--accent));color:#fff;
  padding:5px 14px;border-radius:999px;font-size:.82rem;font-weight:600}
.kv{display:grid;grid-template-columns:auto 1fr;gap:6px 18px;margin:12px 0}
.kv dt{color:var(--ink-dim);font-weight:600;font-size:.86rem}
.kv dd{margin:0}
.aliases{color:var(--ink-soft);font-style:italic}

.tabs{display:flex;gap:4px;border-bottom:1px solid var(--stroke);margin:10px 0 16px;flex-wrap:wrap}
.tabs button{border:0;background:none;color:var(--ink-soft);padding:10px 14px;cursor:pointer;
  border-bottom:2px solid transparent;font-weight:500;font-size:.95rem}
.tabs button.on{color:var(--ink);border-bottom-color:var(--brand)}
.tabpane{display:none} .tabpane.on{display:block;animation:fade .3s}
@keyframes fade{from{opacity:0;transform:translateY(6px)}to{opacity:1;transform:none}}

/* news & citation items */
.feed{display:grid;gap:12px}
.feed .item{border:1px solid var(--stroke);border-radius:var(--radius-sm);padding:14px 16px;background:var(--panel)}
.feed .item a.t{font-weight:600;color:var(--ink)}
.feed .item a.t:hover{color:var(--brand2)}
.feed .item .src{font-size:.78rem;color:var(--ink-dim);display:flex;gap:8px;margin-top:6px;flex-wrap:wrap}
.cite .cites{font-weight:700;color:var(--brand2)}
.badge-stale{background:rgba(251,191,36,.18);border:1px solid rgba(251,191,36,.4);color:var(--warn);
  font-size:.72rem;padding:2px 8px;border-radius:999px}

/* viz */
.viz-wrap{position:relative;width:100%;height:560px;border:1px solid var(--stroke);border-radius:var(--radius);
  overflow:hidden;background:radial-gradient(circle at 50% 40%,var(--bg2),var(--bg))}
.viz-wrap svg{width:100%;height:100%;display:block}
.viz-legend{position:absolute;top:12px;left:12px;display:flex;gap:12px;flex-wrap:wrap;font-size:.8rem;
  background:var(--panel);border:1px solid var(--stroke);border-radius:10px;padding:8px 12px}
.viz-legend span{display:inline-flex;align-items:center;gap:6px}
.node-tip{position:absolute;pointer-events:none;background:var(--panel-solid);border:1px solid var(--stroke2);
  border-radius:8px;padding:6px 10px;font-size:.82rem;box-shadow:var(--shadow);opacity:0;transition:.1s;max-width:260px}
.viz-legend i.dot,.viz-legend .dot{width:10px;height:10px;border-radius:50%;display:inline-block;flex:none}

/* states */
.loading{display:flex;align-items:center;gap:10px;color:var(--ink-soft);padding:18px}
.spinner{width:18px;height:18px;border:2px solid var(--stroke2);border-top-color:var(--brand);border-radius:50%;animation:spin .7s linear infinite}
@keyframes spin{to{transform:rotate(360deg)}}
.empty{text-align:center;color:var(--ink-dim);padding:34px 10px}
.hidden{display:none !important}

/* pagination + misc */
.pager{display:flex;gap:6px;justify-content:center;margin-top:20px;flex-wrap:wrap}
.pager a,.pager span{padding:7px 12px;border-radius:10px;border:1px solid var(--stroke);background:var(--panel)}
.pager .cur{background:var(--brand);color:#fff;border-color:transparent}
.back{display:inline-flex;gap:6px;color:var(--ink-soft);margin-bottom:12px}
.back:hover{color:var(--ink)}

.site-foot{max-width:var(--maxw);margin:40px auto 24px;padding:18px clamp(16px,4vw,40px);
  color:var(--ink-dim);font-size:.85rem;border-top:1px solid var(--stroke);text-align:center}

/* chips in search field */
.chips-in .tag .d{width:8px;height:8px;border-radius:50%;flex:none}
.chips-in .tag .d.gene{background:var(--gene)} .chips-in .tag .d.symptom{background:var(--symptom)}
.chips-in .tag .d.syndrome{background:var(--syndrome)}
.mode-hint{max-width:680px;margin:12px auto 0;font-size:.86rem;text-align:center}
.mode-hint b{color:var(--ink)}
.search-field .go.hidden{display:none}

/* toolbar row with specialty filter */
.toolbar-row{display:flex;align-items:flex-end;justify-content:space-between;gap:12px;flex-wrap:wrap}
.spec-filter{font-size:.82rem;color:var(--ink-dim);display:flex;flex-direction:column;gap:4px}
.spec-filter select{padding:8px 12px;border-radius:10px;background:var(--panel-solid);color:var(--ink);border:1px solid var(--stroke2);font-size:.9rem}
.badge-all{background:linear-gradient(90deg,var(--gene),var(--brand2));color:#04121a;font-weight:700;padding:2px 9px;border-radius:999px;font-size:.78rem}

/* detail: info grid + sections */
.lead{font-size:1.1rem;color:var(--ink);margin:6px 0 14px}
.info-grid{display:grid;grid-template-columns:repeat(auto-fit,minmax(220px,1fr));gap:12px 20px;margin:4px 0 6px;
  background:var(--panel);border:1px solid var(--stroke);border-radius:var(--radius-sm);padding:16px 18px}
.info-grid dt{color:var(--ink-dim);font-size:.74rem;text-transform:uppercase;letter-spacing:.6px;font-weight:600;margin-bottom:2px}
.info-grid dd{margin:0;font-size:.98rem}
h3.sec{margin:20px 0 8px;font-size:1.12rem}
.sm{font-size:.86rem}

/* two-part map */
.twomap{display:grid;grid-template-columns:1fr 1fr;gap:16px}
.twomap-h{display:flex;align-items:center;gap:8px;margin:0 0 2px;font-size:1.05rem}
.twomap-h .d{width:12px;height:12px;border-radius:50%}
.twomap-h .d.gene{background:var(--gene)} .twomap-h .d.symptom{background:var(--symptom)}
.viz-wrap.half{height:440px;margin-top:8px}
@media (max-width:820px){ .twomap{grid-template-columns:1fr} }

/* feed loading % bar */
.feed-loading{padding:14px 2px}
.pl-row{display:flex;align-items:center;gap:10px;color:var(--ink-soft);margin-bottom:8px}
.pl-label{flex:1}
.pl-pct{font-variant-numeric:tabular-nums;font-weight:700;color:var(--brand2)}
.pl-track{height:8px;border-radius:999px;background:var(--stroke);overflow:hidden}
.pl-fill{display:block;height:100%;width:0;border-radius:999px;background:linear-gradient(90deg,var(--brand),var(--brand2));transition:width .18s ease}

/* feed items */
.feed-head{margin-bottom:10px;color:var(--ink-soft);font-size:.9rem}
.feed-head b{color:var(--ink)}
.feed-src{font-size:.82rem}
.feed .item{position:relative}
.feed .item .sm{margin-top:4px}
.feed .item .rank{position:absolute;top:14px;right:14px;font-size:.78rem;color:var(--ink-dim);font-weight:700}
.chiplet{display:inline-block;background:var(--panel);border:1px solid var(--stroke2);border-radius:999px;
  padding:1px 8px;font-size:.72rem;color:var(--ink-soft);margin-left:4px}
.cite .item .t{padding-right:40px;display:inline-block}

/* pdf button + shared-name lists + diagnostics */
.head-actions{display:flex;gap:8px;align-items:flex-start}
.btn-pdf{display:inline-flex;align-items:center;gap:6px;border:1px solid var(--stroke2);background:var(--panel);
  color:var(--ink);padding:9px 15px;border-radius:12px;font-weight:600;font-size:.9rem;white-space:nowrap;transition:.15s}
.btn-pdf:hover{border-color:var(--brand);transform:translateY(-1px)}
.shared-list{color:var(--ink-dim);font-size:.82rem;margin-top:4px}
.shared-list.gene{color:var(--gene)}
.diag-list{margin-top:10px;text-align:left;display:inline-block;font-size:.82rem;color:var(--bad)}
.diag-list div{margin:2px 0}

@media (max-width:640px){
  .search-field input{font-size:1rem}
  .viz-wrap{height:440px}
  .toolbar-row{align-items:stretch}
  .head-actions{width:100%}
  .btn-pdf{width:100%;justify-content:center}
}